|
KMID : 1161420140170060694
|
|
Journal of Medicinal Food
2014 Volume.17 No. 6 p.694 ~ p.700
|
|
|
Anti-Inflammatory and Antinociceptive Effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in Rodents
|
|
Silva Francilene V.
Oliveira Irisdalva S.
Figueiredo Kayo A.
Melo Francisco B. Junior
Costa Danielly A.
Chaves Mariana H.
Amaral Mauricio P. M.
Almeida Fernanda R. C.
Oliveira Francisco A.
Oliveira Rita C. M.
|
|
|
Abstract
|
|
|
|
The present work reports the anti-inflammatory and antinociceptive activities of the ethanol extract obtained from the stem bark of Sterculia striata A. St.-Hil. & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate. The Ss-EtOH (50?mg/kg) promoted a marked inhibition on the hind paw edema induced by carrageenan or dextran (30% and 73%, respectively). Besides, Ss-EtOH (25?mg/kg) exhibited a slight activity (30%) on the hind paw edema induced by histamin. The Ss-EtOH (12.5 and 25?mg/kg) showed the antinociceptive activity on chemical stimuli induced by acetic acid (65.59% and 38.37%, respectively), formalin, in the initial (35.08% and 31.5%, respectively) and late phases (44.09% and 83.57%, respectively), capsaicin (43.77% and 51.31%, respectively), or glutamate (36.6% and 52.12%, respectively). Regarding the possible mechanism involved in the antinociceptive effect, Ss-EtOH (12.5?mg/kg) showed a decrease in the antinociceptive effect (65.8%) in the acetic acid model after pretreatment with naloxone. Thus, opioid mechanisms might be underlying this response.
|
|
|
KEYWORD
|
|
|
anti-inflammatory, antinociceptive, carrageenan, opioid, paw edema, Sterculia striata
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|